KMID : 0359920090280060653
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Korean Journal of Nephrology 2009 Volume.28 No. 6 p.653 ~ p.657
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A Case of Pa-tient with Wegener¡¯s Granulomatosis Showing Glomerular Immune Deposition in Kidney Biopsy
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Seo Young-Jin
Kim Yoon-Jung Moon Ji-Mi Choi Hae-Yoon Woo Jin-Hyun Choi Seong-Jae Lee Young-Ho Ji Jong-Dae Jeong Woon-Yong Song Gwan-Gyu
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Abstract
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Rapidly progressive glomerulonephritis (RPGN) in Wegener¡¯s granulomatosis patients typically has been characterized by pauci-immune glomerulonephritis (PIGN). In some patients, however, significant amount of glomerular immune deposits was detected and reported that they may have poor prognosis.
A 30 year-old-female visited due to the skin rash of both lower extremities, arthralgia and nasal stiffness. She had sinusitis, lung opacity, and proteinuria. Serologic PR-3 ANCA was positive and histologic findings of nasal cavity and lung also showed necrotizing vasculitis and granuloma. Thus we could diagnose Wegener¡¯s granulomatosis. However, gross hematuria developed and renal function worsened in spite of treatment with high dose prednisolone and oral cyclophosphamide. Therefore we performed a kidney biopsy. The kidney biopsy showed crescentic glomerulonephritis with Ig A deposition in the mesangium. We experienced a case of Wegener¡¯s granulomatosis patient with significant IgA deposition in glomeruli. We report this case with brief review of the literature.
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KEYWORD
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Wegener granulomatosis, Immunoglobulin A (IgA), Immune deposition
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